Ecstasy-Induced Caspase Expression Alters Following Ginger Treatment

نویسندگان

  • Akram Nezhadi
  • Amir Roointan
  • Bagher Pourheydar
  • Fataneh Dabaghian
  • Mehdi Mehdizadeh
  • Sara Soleimani Asl
چکیده مقاله:

Introduction: Exposure to 3-4, methylenedioxymethamphetamine (MDMA) leads to cell death. Herein, we studied the protective effects of ginger on MDMA- induced apoptosis. Methods: 15 Sprague dawley male rats were administrated with 0, 10 mg/kg MDMA, or MDMA along with 100mg/kg ginger, IP for 7 days. Brains were removed to study the caspase 3, 8, and 9 expressions in the hippocampus by RT-PCR. Data was analyzed by SPSS 16 software using the one-way ANOVA test. Results: MDMA treatment resulted in a significant increase in caspase 3, 8, and 9 as compared to the sham group (p<0.001). Ginger administration however, appeared to significantly decrease the same (p<0.001). Discussion: Our findings suggest that ginger consumption may lead to the improvement of MDMA-induced neurotoxicity.

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عنوان ژورنال

دوره 4  شماره 4

صفحات  329- 333

تاریخ انتشار 2013-11

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